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Life is good for all the food items that occupy the shelves at the local supermarket. Frank (Seth Rogen) the sausage, Brenda (Kristen Wiig) the hot dog bun, Teresa Taco and Sammy Bagel Jr. (Edward Norton) can't wait to go home with a happy customer. Soon, their world comes crashing down as poor Frank learns the horrifying truth that he will eventually become a meal. After warning his pals about their similar fate, the panicked perishables devise a plan to escape from their human enemies.